Polygonum anti-fatigue effects on memory and Experimental Research.docVIP

 PAGE \* MERGEFORMAT 12 Polygonum anti-fatigue effects on memory and Experimental Research [Abstract] Objective To study the fleece-flower root on learning and memory and its resistance to fatigue. Methods jumping test, water maze and climbing pole test, swimming test and determination of liver glycogen (anti-fatigue effect), were observed in low medium and high dose (2.6,7.8,23.4 g / kg) Polygonum extracts improve memory function in mice and anti-fatigue effects. Results step down test results show that the high dose group on day 1 of testing and re-test after 24 h , the animals the average number of errors were significantly reduced (P lt;0.05); water maze test showed that the high dose group animals, the average number of errors decreased (P lt;0.05). In the fatigue experiments, the climbing pole test results show that high doses of Polygonum extract can significantly prolong the time at the insistence of plexiglass rod (P lt;0.05). loading dose animals was found swimming Gao survival time was significantly longer compared with the normal, anatomical determination of liver glycogen after the discovery of low dose group was significantly lower liver glycogen. Conclusion 23.4 g / kg of fleece-flower root access to the memory of mice to improve the role, medication greater than 7.8 g / kg of fleece-flower root function improved significantly against the effects of fatigue. [Keywords:] Polygonum; memory access; memory representation; anti-fatigue Abstract: Objective To explore the memory and anti fatigue effects of Polygonum multiflorum on mice. Methods The effects of Polygonum multiflorum extract on memory and anti fatigue in mice were studied by step down test, Morris water maze test, pole climbing test, weight loaded swimming test and hepatic glycogen test (anti fatigue experiment) at low, medium and high doses (2.6,7.8, and 23.4 g / kg), respectively. Results In the step down test, the average number of mistakes reduced significantly in the mice