Polygonum Decoction on isolated guinea pig heart and rabbit aortic smooth muscle Mechanism of.docVIP

 PAGE \* MERGEFORMAT 5 Polygonum Decoction on isolated guinea pig heart and rabbit aortic smooth muscle Mechanism of [Abstract] Objective To observe the Huzhang Decoction on isolated guinea pig heart the right atrium and rabbit aortic smooth muscle and its mechanism. Methods guinea pig right atrium, or placed in isolated rabbit aortic smooth muscle tank, using polygraph records changes in its activities. Results Huzhang can speed up the rate of isolated guinea pig right atrium, can reduce rabbit aortic smooth muscle resting tension. Conclusion Huzhang on isolated guinea pig right atrium increased the rate of fast effect may be related to α -adrenergic receptor, β receptors, Ca2 related, has nothing to do with the M receptor; Polygonum vasodilative effect may be related to α -adrenergic receptor, H1-receptor , and β -adrenergic receptor, Ca2, M receptor has nothing to do. [Keywords:] Huzhang rabbit aortic smooth muscle of guinea pig right atrium of heart rate Tension AbstractObjectiveTo research the effects and mechanisms of Huzhang on isolated right atria in guinea-pig heart and isolated rabbit vascular smooth muscle. MethodsRight atrias of guinea-pig and rabbit vascular smooth muscle were suspended in smooth muscle chambers, isolated right atria rates and resting tension of rabbit vascular smooth muscle were recorded.ResultsHuzhang increased the rates of guinea-pig isolated right atria, and decreased the resting tension in rabbit aorta. ConclusionThe effect of Huzhang on the rates of isolated right atria in guinea-pig heart may be mediated via α - receptor, β -reccptor, Ca2, but not be related to M-receptor; the effect of Huzhang on the rabbit aorta may be mediated via α -receptor, H1-receptor, Ca2, but not be related to β -reccptor, Ca2, and M-receptor. Keywords:Huzhang; Right atrias of guinea-pigs; Rabbit vascular smooth muscle; Rate; Resting tension Polygonum cuspidatum Polygonum section Polygonum perennial herb Polygonum cuspidatum Polygonum cuspida