Polygonum multiflorum the chemical composition and pharmacological research.doc

 PAGE \* MERGEFORMAT 14 Polygonum multiflorum the chemical composition and pharmacological research Abstract In recent years, fleece-flower root of the chemical constituents and pharmacological effects to make an overview of the status quo, and its prospect. 【Key Words】 Polygonum multiflorum; chemical composition; pharmacological activity; Research Status A chemical composition Fleece-flower root key contains anthraquinones, stilbene glycosides and polymerization of procyanidins, etc. In addition, fleece-flower root also contains large amounts of lecithin and a variety of trace elements. Polygonum multiflorum stilbene glucoside is the main active ingredient. Li, North and other products from Sichuan Polygonum multiflorum root of ethyl acetate in part by 16 known compounds, the manager of constants and spectral analysis, identified as emodin, emodin, emodin 1,6 - dimethyl ether, etc. [1]. ZHOU Li-Xin et al [2] again in ethyl acetate-insoluble part of the fleece-flower root were isolated 5 monomer; Chen Wan-sheng, et al [3] from the system of fleece-flower root of n-butanol fraction were isolated and identified five compounds were two new compounds. 2 Pharmacology 2.1 Anti-aging role of fleece-flower root can extend the growth cycle of diploid cells, so that strong cell development [4]. Can significantly reduce the aged mice brain and liver tissue malondialdehyde (MDA) content, increased brain levels of monoamine neurotransmitters, increasing SOD activity, but also significantly inhibited the aged mice brain and liver tissue monoamine oxidase-B activity , thereby eliminating the free radicals on the body damage, anti-aging and disease incidence [5]. In addition, the fleece-flower root in aged rats can significantly improve the peripheral lymphocyte DNA damage and repair capacity, regulate central nervous system activity, slow down brain aging [6]. 2.2 The neuroprotective effect of Zhang et al [7] reported