Polysaccharide aging mice on anti-aging effects.doc

 PAGE \* MERGEFORMAT 11 Polysaccharide aging mice on anti-aging effects [Abstract] Objective To study the anti-aging effects of polysaccharides. Methods of polysaccharides of aging mice were divided into high, medium and low-dose group and the aging model group, n = 10, the standard control group of young mice . low, medium and high dose groups were fed the same dose per day (100,200,300 mg / kg body weight) of polysaccharide, a total of 30 d. aging group and the standard control group were fed the same daily dose (1 ml of saline. The results of each dose of polysaccharides in aged mice could reduce serum and brain tissue malondialdehyde (MDA, Nitric Oxide (NO, lipofuscin (LPF content and significantly increased superoxide dismutase ( SOD, glutathione peroxidase (GSH Px activity and the thymus, spleen, liver index. Conclusion Polysaccharides by improving the metabolism of free radicals may play a role in anti-aging. [Keywords:] anti-aging, Polysaccharides, superoxide dismutase, lipofuscin, antioxidant, mice Purslane is an annual herb, with food and medicine duality. Previous studies showed that purslane can be the treatment of acute enteritis, dysentery, diarrhea (1). Modern medical research showed that purslane has anti-cancer (2), antioxidant on human red cell membrane has a protective effect (3). In recent years, purslane was also used to treat hyperlipidemia, coronary heart disease and atherosclerosis and other age-related diseases, received a good response (4). Zhu Huan (5 ) reported Polysaccharides extraction and clearance by the free radical effect, but Polysaccharides in vivo antioxidant, has not been studied. Polysaccharides To investigate whether the role of aging, this study studies of polysaccharides on the aging effects of oxidative stress in mice, further studies of the pharmacological effects of polysaccharides. 1 Materials and Methods 1.1 Animals Aging mice and 12 months old, body weight (45 + -3) g, 40 only, male and female, y