Porphyromonas gingivalis strains induced degranulation in vitro leukocyte.doc

 PAGE \* MERGEFORMAT 10 Porphyromonas gingivalis strains induced degranulation in vitro leukocyte Of: Shen Yuqin LASER Mengxiu Ping Zheng Yi [Abstract] Objective To study the bacteria Porphyromonas gingivalis and its soluble virulence factor on human polymorphonuclear leukocytes and to explore the occurrence of chronic periodontitis in rats. Methods in peripheral blood collected from healthy in the elderly, the use of transmission electron microscopy Observation of polymorphonuclear leukocyte culture group (control group and the bacteria Porphyromonas gingivalis sonicate filtrate incubated group (experimental group, polymorphonuclear leukocyte degranulation. Results The polymorphonuclear leukocyte obvious morphological changes, while the control cells no significant change in the experimental group degranulation leukocyte percentage than the control group increased significantly (P lt;0.001. Conclusion Pg Aeromonas induced polymorphonuclear leukocytes particles to cells around the move and emerge, thereby reducing the host’s immune in the pathogenesis of chronic periodontitis has an important role. [Keywords:] Porphyromonas gingivalis bacteria, polymorphonuclear leukocytes, degranulation Chronic periodontitis in the elderly in the prevalence of high lead in the elderly population is the main reason for missing teeth. Bacterium Porphyromonas gingivalis (Porphyromonas gingivalis, Pg is suspected pathogens of chronic periodontitis is one important (1), through its soluble products on periodontal tissue damage, and polymorphonuclear leukocytes (polymorphonuclear leukocytes, PMNLs is the body against invading bacteria first line of defense (2). pathogenesis of periodontitis, the host’s own resistance power difference is an important factor, PMNLs function of normal or not, is directly related to the level of immunity. study found that: the interaction between periodontal pathogens and PMNLs in the pathogenesis of periodontal disease may play an important