Power for learning and memory and the hippocampus of diabetic rats connective tissue growth factor expression.docVIP

 PAGE \* MERGEFORMAT 14 Power for learning and memory and the hippocampus of diabetic rats connective tissue growth factor expression Study: Ping Ma, Ji, the in route, Chu Yurong [Abstract] Objective To observe the power of cognitive dysfunction for the diabetic rats improved learning and memory in the hippocampus and its effect on connective tissue growth factor (connective tissue growth factor, CTGF) mRNA and protein expression. Methods intraperitoneal injection of 20g / L streptozocin (streptozotocin, STZ) diabetic rat model constructed, the model rats were randomly divided into acupuncture group (EA), model group (DM), normal (CN). electroacupuncture in rats were measured after 4 weeks blood glucose level, the application was observed Morris water maze learning and memory power for the impact of diabetic rats, and used RT PCR and immunohistochemistry to detect CTGF mRNA and protein expression in hippocampus. Results model of blood glucose, higher than the normal group and the latency stage EA group (P lt;0.01), model group CTGM mRNA and protein expression was significantly lower than the normal group and EA group (P lt;0.01). Conclusion Electroacupuncture can lower blood sugar to some extent, promote CTGF mRNA and protein expression in the hippocampus, improve diabetes cognitive impairment, learning and memory and cognitive function. [Keywords:] acupuncture, blood glucose, learning and memory, hippocampus, connective tissue growth factor ABSTRACT: Objective To observe the effect of electroacupuncture on improvement of learning and memory ability and the expression of connective tissue growth factor (CTGF) mRNA and protein in hippocampus in diabetic rats with cognitive impairment. Methods The rat diabetes model was induced by injecting streptozotocin ( 20g / L), and then the rats were randomly divided into three groups: electro acupuncture group (EA), diabetes mellitus untreated group (DM) and control group (CN). After four weeks of electroacupun