Preparation of lansoprazole enteric-coated tablets.docVIP

 PAGE \* MERGEFORMAT 10 Preparation of lansoprazole enteric-coated tablets [Abstract] A cross-linked sodium carboxymethyl cellulose as a disintegrating agent, PVP-K30 as a binder, anhydrous ethanol as solvent, through the rule of law must step granulation Lansoprazole granules, tablet packets were isolated after the clothing and enteric coated lansoprazole enteric-coated tablets obtained. The test results are in line with requirements. [Keywords:] step granulation lansoprazole enteric-coated tablets [Abstract] Lansoprazole enteric-coated tablets were prepared by One-step-granulating method, using cCMC-Na as disintegrant, povidone K30 as adhesive, enteric Opadry as coating material, anhydrous ethanol as solvent and then mixed with other excipients to get its enteric -coated tablets. The results showed the enteric-coated tablets complied with the requirements. [Keywords:] lansoprazole; enteric-coated tablets; One-step-granulating method Lansoprazole (Lansoprazole) [1] as the second-generation proton pump inhibitors, developed by Japan’s Takeda, mainly for the treatment of gastric ulcer, duodenal ulcer, reflux esophagitis, Jordan - Ai (Zollinger - Ellison) syndrome (gastrinoma), anastomotic ulcers. At present, although there are lansoprazole enteric-coated tablet market, but the ordinary wet granulation, bioavailability is low and less stable, the author now lansoprazole dissolved in anhydrous ethanol, using a step granulation granulation, tabletting, respectively, after packets gown obtained with the enteric coating of lansoprazole enteric-coated tablets. The test results show that the goods comply with the requirements at the same time stability study results show that the product was stable in 18 months. An instrument and reagent UV-2401PC UV Spectrophotometer, LC-10AD-based high-performance liquid chromatography (Shimadzu, Japan); RCZ-5A Intelligent Dissolution Tester (Tianjin University Radio Factory); Glatt fluidized bed granulator step (Shanghai Guer