Primary liver cancer molecular mechanisms of pathogenesis of.docVIP

 PAGE \* MERGEFORMAT 13 Primary liver cancer molecular mechanisms of pathogenesis of [Keywords:] primary liver cancer; molecular mechanism Primary liver cancer (primary hepatocellular carcinoma, HCC) is the liver cells or intrahepatic bile duct cancer cells, is a high rate of malignancy and metastasis of tumors. In recent years, molecular biology techniques along with advances in research on the pathogenesis of HCC become more in-depth. A tumor suppressor gene and HCC Many genes involved in HCC formation changes, the accumulation of genetic changes caused by control of cell growth and differentiation mechanism of the disorder, but the balance between growth and differentiation is controlled by two types of genes: oncogenes and tumor suppressor gene. Involved in cell proliferation and tumor suppressor genes, apoptosis and DNA replication process, its expression led to loss of control the occurrence and development of HCC. 1.1 WWOX gene (WW  domain containing oxidoreductase, WWOX) is located in dyeing 16q23.3  q24, its encoded protein has two WW domains, as well as a short-chain dehydrogenase / reductase structure (short  chain dehydrogenase / reductase domain, SRD). It is with c  Jun, TNF, p53, p73, AP  2γ and the interaction of E2F  1 and so on, through the transcriptional repression and the promotion of apoptosis of tumor suppressor to achieve the purpose of promoting apoptosis in which the function is particularly important . WWOX tumor suppressor mechanism: ① the transcription factor AP  2γ isolated from within the cytoplasm and inhibit its transcriptional activity [1]; ② trigger the re-distribution of p73 and inhibit its transcriptional activity, the activation of apoptosis [2]; ③ raise P53 and reduced Bcl  2 and Bcl  XL, promote cell apoptosis [3]. WWOX gene deletion mutation, or frameshift mutations lead to a different domain of the partial or complete loss of the formation of different forms of WWOX transcripts. WWOX a variet