Preparation of solid lipid nanoparticles of ibuprofen.docVIP

 PAGE \* MERGEFORMAT 10 Preparation of solid lipid nanoparticles of ibuprofen Of: Wudong Dong Wei Zhong Min Pang Xiu-Juan Yu Kefu [Abstract] Objective To prepare ibuprofen solid lipid nanoparticles (solid lipid nanoparticles, SLN and optimize their prescription. Emulsifying Methods - Preparation of ibuprofen ultrasound SLN, the entrapment efficiency evaluation index, the orthogonal experimental screening optimal prescription. Results orthogonal screening, the best prescription for ibuprofen, 0.05 g, F-68 0.35 g, n-butanol 2 mL, lecithin 0.15 g, glycerol monostearate 0.05 g. Conclusion The process and the preparation of the ibuprofen prescription properties of SLN formulations meet the requirements. [Keywords:] Preparation of solid lipid nanoparticles containing ibuprofen Formulation SLN was discovered in recent years a new type of nanoparticle drug delivery system, with a small particle size, physiological acceptable to extend the drug release and can realize the advantages of targeted drug delivery [1]. Ibuprofen antipyretic analgesic and anti-inflammatory effects with non-steroidal anti-inflammatory drugs, mainly for the treatment of rheumatism and rheumatoid arthritis, but after oral administration to eliminate speed, multiple doses required to maintain efficacy, and long-term medication will be cause gastrointestinal side effects [2]. will be made of solid lipid nanoparticles for ibuprofen intravenous injection or direct injection at the target site can play a role in their release, reducing the number of drug use, improve patient compliance. 1 apparatus and materials LS-05 high performance liquid chromatography (LC-10UV detector, LC-05P liquid pumps, Dalian Jiang Shen Separation Science and Technology Corporation), DZKW electronic constant temperature water bath (Guangming Medical Instrument Factory Beijing Yong, DJ1C power by force stirrer (Jintan City, Jiangsu Province, land of Automation Instrument Factory, JY92-2D ultrasonic cell crus