Potentilla discolor flavonoids on serum of diabetic mice The role of insulin and insulin antibodies.docVIP

 PAGE \* MERGEFORMAT 7 Potentilla discolor flavonoids on serum of diabetic mice The role of insulin and insulin antibodies Authors: WANG Xiao-min, Zou Zhijian, Chen Mei, Feng Jinsong [Abstract] Objective To observe the Potentilla discolor flavonoids on diabetic mice blood glucose and serum insulin and insulin resistance. Methods Potentilla discolor by the solvent extraction and polyamide column separation to mention access to flavonoids extract; by intraperitoneal injection of alloxan-making model will be a successful modeling of mice were randomly divided into a high-dose (216 mg * kg-1 * d-1 ), low dose (108 mg * kg-1 * d-1), model control group. Continuous administration of 14 d after the observation of flavonoids from Potentilla discolor diabetic mice body weight, blood glucose, serum insulin and insulin antibody effects. Results Potentilla discolor flavonoids can well reduce the diabetic mice blood glucose, serum insulin level increased, but little effect on serum insulin antibody. Conclusion Potentilla discolor the therapeutic effect of flavonoids on diabetes, possibly by lowering blood sugar levels and increase serum insulin levels achieved. [Keywords:] Potentilla discolor flavonoids glucose-insulin-insulin antibody Abstract: ObjectiveTo study the effects of flavonoids from Potentilla discolor Bunge. (FPB) on the blood glucose, the levels of insulin and insulin antibody in serum in diabetes mice and its mechamisms. MethodsFPB were obtained from Potentilla discolor Bunge. Through solvent extraction and polyamide columnar Chromatography. The model mice of alloxan-diabetes were randomly divided into these groups: high dose group (216 mg * kg-1 * d-1), low dose group (108 mg * kg-1 * d-1) and model group. Body weight, blood glucose, the levels insulin and insulin antibody in serum were measured after 14 days.ResultsFPB decreased blood glucose and enhanced level of insulin in serum, but level of insulin antibody in serum was not significantly chan