Preparation of traditional Chinese medicine using fluidized bed technology of coating particles.docVIP

 PAGE \* MERGEFORMAT 6 Preparation of traditional Chinese medicine using fluidized bed technology of coating particles [Abstract] Objective To prepare the medicine coated particles, optimizing the preparation process. Methods fluidized-bed fluid bed tangential spray method and spray coating of the compound at the end of Geranium colon-specific drug particles prepared by Process. The results of the optimized formulations prescription for the extract powder and carboxymethyl starch sodium, microcrystalline cellulose ratio of 8:1:1, fluidized bed tangential spray parameters are inlet temperature 30 ℃ , fan frequency of 15 Hz, turntable rotational speed 500 r / min, spheronization time, 60 min; bottom-spray coating process conditions for the flow rate 2 ml / min, atomization pressure of 0.1 MPa, fan frequency of 25 Hz, inlet air temperature of 30 ℃ . Conclusion The process is reasonably practicable, spherical particle shape is good, high rate of coated finished product. [Keywords:] Geranium coated particle fluidized bed granulation Abstract: ObjectiveTo prepare coating granules of traditional Chinese medicine and optimize the preparation technology. MethodsAdopting tangent spraying and bottom spraying method of fluidized-bed to research the prepare technology of colon targeting granules of complex prescription geranium. ResultsThe best proportion of powdered extract, CMS - Na and MCC were eight, one and one. Fluidized-bed tangent spraying technology were rolling speed 500 r / min, spheronization time 60min. The best film coating technology conditions were 2 ml / min of flow rate, 0.1 MPa of atomization pressure, 25 Hz of breeze machine, 30 ℃ of breeze temperature. ConclusionThe technology is reasonable and feasible. Shaping of spheroidal particle is good and finished product coating rate is high. Keywords:: Geranium; Coating granules; Fluidized bed granulation Fluidized-bed granulation, coating has been widely applied in the domestic pharmaceutical companie