Primary lymphoma of nasal cavity and sinuses Progress.docVIP

 PAGE \* MERGEFORMAT 16 Primary lymphoma of nasal cavity and sinuses Progress [Keywords:] lymphoma, nasal and sinus cancer Lymphoma is a primary in the lymph nodes or lymphoid tissue malignancies, usually in the form of solid tumor growth in organs rich in lymphoid tissue, in which lymph nodes, tonsils, spleen and bone marrow involvement are most vulnerable. But there are also starting outside the lymphoid tissue in lymph nodes or non-lymphoid tissue lymphoma of organs, known as primary extranodal lymphoma. The incidence of the top five most common sites were the gastrointestinal tract, nasal cavity, Waldeye ring, spleen, skin [1]. Lymphoma is divided into Hodgkin’s disease (Hodgkin’s disease, HD) and non-Hodgkin lymphoma (non-Hodgkin’s lymphoma, NHL). Lymphomas originating in the nasal cavity and paranasal sinuses, mostly NHL, the incidence in recent years, an increasing trend year by year and the lack of specific clinical manifestations, easily missed and misdiagnosed. The author’s research progress to the disease are reviewed. A pathological and immunohistochemical classification WHO recommendations should be the composition of lymphoid cells in the tumor phenotype and molecular genetic analysis to be classified [2]. Immunohistochemistry can be divided according to T, B and NK / T cell lymphoma subtypes [3]. The original recurrent nasal and paranasal sinuses have a variety of different types of lymphoma, immunohistochemical features, B cell lymphoma showed B cell markers CD20, CD79a, T cell lymphomas showed T cell markers CD3, CD45RO, CD43 negative [4], part of the B cell lymphoma express CD20 and CD43 double [5,6]. NK / T cell lymphoma associated antigen expression, have a special immune phenotype and genotype, ie: T cell markers CD2, CD7, CD8 may be positive, surface CD3 positive, but the cytoplasm in paraffin section CD3 (CD3ε)-positive, T cell receptor βγδ (TCRβγδ no clonal rearrangement, identification of specific monoclonal antibody CD