Primary small vessel vasculitis patients with multiple system analysis of clinical manifestations and renal pathology.docVIP

 PAGE \* MERGEFORMAT 14 Primary small vessel vasculitis patients with multiple system analysis of clinical manifestations and renal pathology Study: Solutions Li Yi, Xue Wujun, Feng Tan, Lu Wan Hong, Lu Jing, Yin Aiping, Ping Xueliang [Abstract] Objective To analyze the primary small vessel vasculitis patients with multiple system clinical manifestations and renal pathology. Methods in our hospital from January 1996 to August 2007 between the diagnosis of primary small vessel vasculitis patients with a total of 78 cases, patients had kidney damage, concurrent biopsy, analyzed clinical and pathological data of patients. Results of 78 cases 15 cases cytosolic anti-neutrophil cytoplasmic antibodies (cANCA)-positive, were identified proteinase 3 (PR3), 62 Ring-type anti-nuclear neutrophil cytoplasmic antibodies (PANCA) positive, were identified myeloperoxidase (MPO). clinical manifestations of multiple organ involvement: irregular fever, edema, hematuria, proteinuria, renal dysfunction, cough , hemoptysis, chest pain, pulmonary infiltrates, accompanied by purulent nasal discharge, joint swelling and pain and so on. biopsy shows segmental small vessel wall fibrinoid necrosis, crescent common. immunofluorescence immunoglobulin or no trace immunoglobulin and complement C3 deposition. Treatment with glucocorticoids or cytotoxic drugs combined with mycophenolate mofetil, some patients are also given to dialysis treatment, the therapeutic efficacy rate of 85.9%. Conclusions are not uncommon primary small vessel vasculitis , and the microscopic polyangiitis type of mostly middle-aged patients to the main, ANCA testing can help determine the early diagnosis and recurrence, prompt treatment can be reversed. [Keywords:] vasculitis, antineutrophil cytoplasmic antibodies and renal biopsy ABSTRACT: Obiective To analyze the clinical and pathological characteristics of primary small-vessel vasculitides. Methods Totally 78 patients with primary small-vessel vasculitide