Pro-apoptotic genes bad blood vessels in the skin tumor tissues.doc

 PAGE \* MERGEFORMAT 17 Pro-apoptotic genes bad blood vessels in the skin tumor tissues 【Key Words】 bad;,, hemangioma;, and apoptosis;,, immunohistochemistry,,,, Abstract: Objective: To investigate the pro-apoptotic gene bad blood vessels in the skin tumors and its association with the clinical relationship. Methods: Immunohistochemical staining to detect human skin hemangioma in proliferative phase, degradation period and the normal skin tissue the expression level of bad use of computer image analysis techniques to measure the different periods of hemangioma and normal skin tissue the expression of bad average optical density and the average positive area. Results: The image analysis results showed that proliferative phase group, the average optical density of 0.0496 ± 0.0152; degradation stage group, the average optical density of 0.1751 ± 0.0349; normal skin group, the average optical density of 0.0524 ± 0.0164. Proliferative phase group of positive area ratio of 0.1047 ± 0.0103; degenerating group positive area ratio of 0.2943 ± 0.0371; normal skin group positive area rate of 0.1103 ± 0.0132. The q test group and the proliferative phase degradation phase group, degradation phase group and between groups of normal skin, bad, the average optical density and the positive area ratio, a significant difference (P lt;0.01), proliferative phase group and between groups of normal skin average optical density and the positive area ratio of the difference was not significant (Pgt; 0.05). Conclusion: bad hemangioma endothelial cells by inducing apoptosis and promoting Angioma transition from hyperplasia to degradation. Keywords: bad; hemangioma; apoptosis; immunohistochemistry Hemangiomas are the most common in infants a benign tumor, its incidence rate is about 10%, male to female ratio is 1:3. The current adult cases are not uncommon. This benign tumor in infants after birth through endothelial cell proliferation and rapid growth, although s