Progress in the diagnosis of Helicobacter pylori infection_0.docVIP

 PAGE \* MERGEFORMAT 16 Progress in the diagnosis of Helicobacter pylori infection [Abstract] Helicobacter pylori infection and chronic gastritis, a major cause of peptic ulcer is a risk factor for gastric cancer, but also many diseases and stomach outside. With the deepening of the Helicobacter pylori research, new diagnostic methods and means of continuously applied to the diagnosis of H pylori which, this paper reviewed their progress. [Keywords:] Helicobacter pylori, diagnosis, new development Helicobacter pylori (Helicobacter pylori, H pylori) is not only chronic gastritis, peptic ulcer of the major pathogens, but also lead to gastric cancer risk factors, World Health Organization, IARC has cancer of the original bacteria into the first category, and also associated with many diseases outside the stomach [1,2]. H pylori infection is a worldwide, people in the world in more than 50% rate of chronic infection, the infection rate of our population 50% to 80% [2] . At present the clinical diagnosis of H pylori infection method broadly divided into two categories: (1) invasive methods, invasive and gastric mucosa by endoscopic biopsy for bacterial culture, histopathology and rapid urease test, magnifying endoscopy inspection . (2) Non-invasive methods of serology, 13C, 14C urea breath test, polymerase chain reaction (PCR), H pylori stool antigen test, urine test H pylori antibodies, proteomics and Western blotting techniques [3 ~ 5]. 1 invasive procedures 1.1 Histological examination [6] H pylori infection in histological detection method is widely used in the method of diagnosis, the pathologist can recognize the typical form of H pylori, while the type of evaluation of gastritis and recognize pre-cancerous (atypical hyperplasia , IM, etc.) or obvious tumor lesions. histologic high sensitivity (90% -95%), but the whole operation depends on the observer’s experience and technology, the larger the difference between the sensitivity of laboratory a