Qi decoction on serum levels of radiation-induced lung injury in transforming growth factor-β1 and γ-IFN in.doc

 PAGE \* MERGEFORMAT 11 Qi decoction on serum levels of radiation-induced lung injury in transforming growth factor-β1 and γ-IFN in Of: Lifeng Yu, Wang Bingsheng, Liu Xiufang, Zhang, Shi Jun, Zhang Jianyu, Geyan Li, Ren Chengbo [Abstract] Objective To observe the small dose of medicine Yiqihuoxue repeated irradiation at different phases of serum transforming growth factor-β1 (TGF-β1), γ-interferon (γ-IFN) and to explore its radiation-induced lung injury The preventive effect and possible mechanisms. Methods 120 Wistar female rats were randomly divided into 30 traditional Chinese medicine group irradiation, irradiation and ambroxol group 30, 30 irradiation group and control group 6. with a linear accelerator of the former 3 rats were fractionated irradiation lung (5 Gy / time, 1 time / week, cumulative doses of up to 30 Gy), the irradiation 4,6,8,12,26 weeks after the start time point were killed 5 Rat, ELISA detection of serum samples obtained, the rats were observed at different phases of serum TGF-β1, γ-IFN dynamic changes. Results irradiation of serum TGF-β1 in the first 4 weeks of exposure increased, the first 12 weeks reached a peak 26 weeks slightly decreased, while the γ-IFN began to decrease at 4 weeks, 12 weeks down to speed up to 26 weeks of gradual recovery. exposure to traditional Chinese medicine group at each time the expression of TGF-β1 serum levels were lower than irradiation group, and γ-IFN were higher than the irradiation group (P 0.05). Conclusion Yiqihuoxue medicine to inhibit TGF-β1 secretion, and promote the role of γ-IFN secretion, suggesting that it may have to reduce inflammation in early and late radiation radiation-induced pulmonary fibrosis, prevention and treatment of radiation-induced lung injury has a role. [Keywords:] radiation-induced lung injury, transforming growth factor-β1, γ-interferon, Yiqihuoxue medicine, rat Abstract: Objective To observe the effect of Yiqi Huoxue Recipe on the expression of TGF-β1