Qian Yang mixture on blood pressure and heart rate in spontaneously hypertensive rats the impact of.docVIP

 PAGE \* MERGEFORMAT 17 Qian Yang mixture on blood pressure and heart rate in spontaneously hypertensive rats the impact of [Abstract] Objective To observe and Yang mixture (hereinafter referred to as QYHJ intervention in spontaneously hypertensive rats (SHR’s blood pressure. Methods 11 week old male SHR 40 were randomly divided into 5 groups: QYHJ high, medium and low doses of 3 groups , fosinopril group and model control group, n = 8. Another to eight week old male WKY rats with normal control group. QYHJ high, medium and low dose group and dose were 22.94,11.47 5.74 g / kg, administered dose of fosinopril group was 0.9 mg / kg, continuous administration of 8 weeks. model group and normal control group were given equal amount of distilled water. before treatment and every 2 weeks after the tail are Pressure measurement of blood pressure and heart rate, each measured 3 times the average. Results The control group heart rate, blood pressure, higher than the normal control group (P lt;0.001, drug intervention, the fosinopril group and high dose group QYHJ lower than the model group (P lt;0.001, P lt;0.01,14 weeks of age, compared with the week fosinopril group model of heart rate were decreased (P lt;0.01, 18 weeks of age, QYHJ high dose group compared with the same heart rate weeks of model control group decreased (P lt;0.001. fosinopril group, QYHJ high blood pressure in doses lower than the model group (P lt;0.001, QYHJ comparison between different dose groups showed, QYHJ high, medium dose group blood pressure lower than QYHJ low dose group (P lt;0.001, QYHJ QYHJ in the high dose group than in the lower dose group, but no significant difference between the .14 weeks of age, blood pressure compared with fosinopril weeks of model control group lower (P lt;0.05,16 weeks of age, QYHJ high dose group compared with the week-old model of blood pressure were decreased (P lt;0.001. Conclusion QYHJ SHR with a lower heart rate and blood pressure, QYHJ certain antihy