Quetiapine and risperidone in the treatment of vascular dementia A comparative study of psychiatric symptoms.docVIP

 PAGE \* MERGEFORMAT 11 Quetiapine and risperidone in the treatment of vascular dementia A comparative study of psychiatric symptoms [Abstract] Objective: To compare the quetiapine and risperidone in the treatment of psychiatric symptoms in vascular dementia the efficacy and safety. Methods: from May 2007 to May 2009 hospitalization 60 patients with vascular dementia were randomly divided into two groups of 30 patients, one group was treated with quetiapine (Rev D) 150 ~ 300 mg / d treatment (quetiapine group), another group was given risperidone (Sili Shu) 1 ~ 3 mg / d treatment (risperidone group) were treated for 6 weeks. before and after treatment in the treatment of the first 1,2,4,6 weekend, with positive and negative syndrome scale (PANSS) to assess the clinical need to deal with the bad treatment Symptom Scale (TESS) assessment of safety. Results: In the first 6 weeks of treatment, quetiapine group and 73.3%, risperidone group was 70.0%, the difference was not statistically significant (Pgt; 0.05); seroquel Ping Group 1 week of treatment, positive symptoms score, score and total score of general pathology that is significantly decreased (P lt;0.05 or P lt;0.01), while risperidone in the treatment of the first 2 weeks, PANSS only the points decreased significantly (P lt;0.01), and with the treatment time, the PANSS score in both groups continued to decline, and in 1 week, reduced hours of quetiapine group was higher than risperidone group, and in the treatment of 2,4,6 weekend risperidone reduced rate compared with no significant difference (Pgt; 0.05); at 6 weeks of observation period, two groups the incidence of adverse reactions was no significant difference (Pgt; 0.05 ), but the combined use of risperidone during treatment of benzodiazepine medicines more than the quetiapine group, the difference was statistically significant (P lt;0.05). Conclusion: Quetiapine and risperidone are the spirit of vascular dementia Symptoms are effective, safe, effec