Rabbits in the steroid-induced femoral head necrosis of the significance of changes in hepatic lipase.doc

 PAGE \* MERGEFORMAT 7 Rabbits in the steroid-induced femoral head necrosis of the significance of changes in hepatic lipase Author: Yi-fu, Liu, Meng Lin, Yuan Zhi, LU Rong, Yuan Peng [Keywords:], femoral head necrosis Change of hepatic lipase and its meaning during the glucocorticoidinduced avascular necrosis of femoral head in rabbits [Abstract] AIM: To elucidate the change of hepatic lipase (HL) activity and its meaning during the glucocorticoidinduced avascular necrosis of the femoral head (NFH). METHODS: Forty mature New Zealand white rabbits were randomly allocated to 4 groups: group A served as control; group B were given dexamethasone at a dose of 7.5 mg / kg iv per day for the 1st week, then at a dose of 2.5 mg / kg im every other day; group C, given dexamethasone just as group B, were also given testosterone propionate at a dose of 5 mg / kg im every 3 d at the same time; group D only received testosterone propionate supra citato. Just before and at the 1st, 3rd, 5th week of the experiment, 12fasted blood samples were collected 15 min after given heparin sodium (at a dose of 50 U / kg iv) to monitor plasma lipid and lipoprotein concentrations and HL activity. Objects were sacrificed in batch randomly and bilateral femoral head were collected to detect bone necrosis index at the 5th and 8th week of the experiment. RESULTS: Compared with group A and group D, the concentrations of TG, TCH and HDL in group B and C were much higher (especially in group B); the HL activity decreased distinctively in group B, but reascended in group C. While compared with group A, the HL activity was higher in group D. At the end of the 8th week in group B, empty lacuna, increased adipocytes and osteocyte necrosis were extremely obvious; but during the 5th week, such changes were not so serious. Similar changes were also found in group C, but the changes were slight. CONCLUSION: Decrease of HL activity and hyperlipemia exist in the process of glucocorticoidinduced NFH,