Recent research neuropathic pain.doc

 PAGE \* MERGEFORMAT 12 Recent research neuropathic pain [Keywords:] Recent research neuropathic pain Neuropathic pain is a central nervous system and peripheral nervous system dysfunction in primary disease or caused pain syndrome. In the population incidence of about 1%. International Study of Pain will be the designated as “primary by the nervous system damage or dysfunction caused by pain, “[1]. A pathological mechanism The pathogenesis of neuropathic pain is complex, since there are still controversial in the academic, the lesion may have been from the peripheral receptors to the brain. Neuropathic pain generally associated with signs of vascular dysfunction and inflammation [2]. Neuropathic pain patients because of acute limb postganglionic sympathetic vasoconstrictor nerve fibers decreased neurotransmitter release caused by skin sympathetic vasoconstrictor nerve excitability loss of function [3]. retrograde peripheral nerve stimulation of sensory input resulting from neurogenic inflammation, including vasodilation, plasma exudation Phi Phi and leukocyte infiltration in the table and the temperature rise produced vasorelaxation plays an important role. in which arterial blood flow in patients with neuropathic pain, venous pressure and increased microvascular permeability were detected by rheology instrument. However, the above limited to the skin test to measure [4]. For a long time, the lack of ideal animal model, people in the pathogenesis of neuropathic pain do not know much, resulting in the treatment of neuropathic pain has been slow. Over the last decade, Several animal models of neuropathic pain to the establishment and improvement in all aspects of neuropathic pain (pathophysiology, electrophysiological mechanisms, medication, etc.) research has made some progress [5,6]. P177 inflammation, mechanical trauma, ischemia, toxicity, metabolism abnormalities and genetic factors can directly or indirectly, the peripheral nervous system and ce