Red blood cells in tumor immunity in the role and status of.docVIP

 PAGE \* MERGEFORMAT 19 Red blood cells in tumor immunity in the role and status of In the process of tumor occurrence and development of immune function plays a very important role in many previous studies only involve the immune system white blood cells, while the red blood cells in which the role has been neglected. 1981, Siegel [1] put forward the red blood cell immune system (Red-cellimmunesystem) new concept, has opened up new areas of the body’s immune system. Present the performance of red blood cell immune function, mechanism, regulation mechanisms and disease relationship studies have made some progress, red blood cells with immune function is beyond any doubt the fact that a large number of studies have shown that red blood cells also have a certain degree of immune function, and thus red blood cells The role and status need to be re-understanding of the aspects of this research synthesis are summarized below. 1 The role of red blood cells in tumor immunity 1.1 to promote phagocytosis Forslid et al [2] found that C3b sensitized yeast, neutrophils, their phagocytic rate was 15%, while adding red blood cells, the phagocytic rate of double red blood cell debris also has the same effect. Authors speculate that the antioxidant substances contained in red blood cells can protect the process of neutrophil phagocytosis in the release of oxygen free radicals on neutrophil cytotoxicity itself, thereby promoting phagocytosis. Xu Ying et al [3] also shows that human red blood cells can significantly promote the peripheral blood polymorphonuclear leukocyte (PMN) phagocytic function, in the presence of red blood cells of yeast phagocytic rate increased about 70%, promoting phagocytosis and erythrocyte complement receptor type 1 (C3breceptor, CR1) on different numbers. The red blood cells and lymphocytes in patients with lung cancer according to a certain steps and through the role of serum sensitized cancer cells to observe the red blood