Redox state and cell signal transduction.docVIP

 PAGE \* MERGEFORMAT 29 Redox state and cell signal transduction Abstract intracellular changes in redox state determines the direction of redox reactions from occurring, and through a certain mechanism of checks and balances. Molecules inside the cell membrane and cell oxidation or reduction reaction, leading to structural or conformational change in the cell signal transduction, gene transcription, etc. played an important regulatory function, cell life activities have an important impact. Tyrosine protein kinase and phosphatase, Sisu histidine kinase and phosphatase, phospholipase and its metabolites, calcium ions and other important signaling molecule through oxidation-reduction reactions mediated signal transduction. This intracellular redox  signal transduction system have been complex and sensitive regulation. Currently at the molecular level, a better understanding of the redox state of cell regulation mechanisms is of great significance. Keywords: redox state; cell; signal transduction 【Abstract】 The diection of cellular redox reaction was determined by redox state.Signal transduction, genetic transciption could be regulated by the change of cellular molecular structure through redox reaction .. Signal transduction could be mediated by redox reaction through protein tyrosine kinase / phosphatase, protein  serine  threonine kinases / phosphatase, phosholipase, calcium ion and other significant signaling molecules.The regulation of redox  signal transduction system was sensitive and complicated.It was important to realize the regulation mechanism of redox state on cellular molecular level. 【Keywords:】 redox state; cell; signal transduction Vivo oxidation-reduction reaction is ubiquitous and important biochemical reactions. Oxidant and anti-oxidant / reductant their activity and decide the ratio between the intracellular redox state. For the cells, the redox state change occurs on the cell membrane and intracellular