Reduced glutathione and atorvastatin combination therapy non-alcoholic steatohepatitis 30 cases of.doc

 PAGE \* MERGEFORMAT 4 Reduced glutathione and atorvastatin combination therapy non-alcoholic steatohepatitis 30 cases of [Keywords:] non-alcoholic steatohepatitis 0 Introduction Non-alcoholic Steatohepatitis (nonalcoholic steatohepatitis, NASH) is the most common one of diffuse liver disease, but its pathogenesis is not entirely clear. Oxidative stress and lipid peroxidation in the pathogenesis of NASH has important role. we intend to explore the antioxidant glutathione, and lipid-lowering drug atorvastatin efficacy of the treatment of NASH, with a view to provide experience for NASH in clinical treatment. A clinical data 1.1 The inclusion criteria NASH reference diagnostic criteria [1,2]: ① aged 18 to 70 years of age; ② B-type ultrasonic examination showed that the near-field echo intensity increased over the liver area of 1 / 2, the far-field echo attenuation, tube-like structure unclear; ③ serum alanine aminotransferase (ALT)amp;gt; 1200 nkat / L. The three are in line with those selected. patients with 61 cases, the Department of 200301/200501 outpatients and inpatients in our hospital, are excluded viral hepatitis, drug-induced hepatitis, various types of liver sclerosis, biliary obstruction. are excluded from malnutrition, total parenteral malnutrition, inflammatory bowel disease, small bowel diverticular disease and inflammatory diseases, non-tropical port. There was no operative history, the recent history of no medication, no history of hereditary metabolic diseases , no history of drinking or alcohol intake amp;lt;20 g / d. unwilling to cooperate with this treatment, pregnant and lactating women are not elected. 1.2 Methods Patients were randomly coded, followed by selection, parallel divided into treatment group and control group. The control group 31 (male 21, female 10) with a mean age of 49.6 ± 6.8 (31 ~ 70) years of age. Which increased serum triglycerides in 21 cases , serum cholesterol increased in 28 cases. 20:00 taking atorvastat