Regional differences and methionine synthase gene polymorphism correlation.doc

 PAGE \* MERGEFORMAT 6 Regional differences and methionine synthase gene polymorphism correlation [Abstract] Objective To compare with other regions of Qinghai normal female methionine synthase gene distribution. Methods using PCR - RFLP technique on 125 cases of normal methionine synthase gene amplification and spectrum analysis, combined with past literature published comparisons between different regions. The results in Qinghai Province in MS normal female genotype A / A up to see, A / G times. A / A genotype frequency of 0.5760, A / G is 0.4160, G / G is 0.0080. Compared with other regions, MS genotype in the normal women in Qinghai Province and other parts of the distribution of population in the distribution of significant difference. Conclusion methionine synthase gene polymorphism in different regions of the distribution varied significantly. [Keywords:] methionine synthase polymorphism geographical differences Abstract Objective To compare the distribution feature ofMethionine Synthase gene between QingHai Province and other regions. Methods The Methionise Synthase genotypes of 125 women in QingHaiProvince were determined by PCR - RFLP assay. Results Ms genotype frequency: A / A 0.5760, A / G 0.4160, G / G 0.0080.The genetypes frequencies of Methionise Synthase in nomal feature of QingHai were different from those in other area in China. Conclusion There has geographical variation in the Methionise Synthase Polymorphism in China. Keywords: Methionine Synthase Polymorphism Geographical variation Study found that serum homocysteine (Hcy) for cardiovascular, cerebrovascular, peripheral vascular system diseases and congenital malformations of the independent risk factors in the occurrence of related diseases, the development process plays an important role. In recent years, the study of Hcy and pregnancy complications have also made significant progress [1]. In the maternity area, the Hcy and fetal congenital malformations, habitual abortion, pre-ec