Relationship between cytokines and the research progress of alveolar bone loss.doc

 PAGE \* MERGEFORMAT 13 Relationship between cytokines and the research progress of alveolar bone loss [Abstract] Periodontitis is a major hazard to human health diseases, is caused by one of the major loss of teeth, alveolar bone resorption is the main pathological changes. Study found that functional overlapping regulation of host cytokines immune response, the formation of a complex regulatory network, activation or inhibition of osteoclast formation, leading to alveolar bone loss or stop the conduct. These cytokines on osteoclast differentiation lead to the regulation of attachment loss and alveolar bone absorption key. [Keywords:] periodontitis; immune Abstract: Periodontal disease, seriously damaging human health, is the main reason for lost teeth. Alveolar bone resorption is the major pathological change. Recent researches reveal that a series of cytokines make up a complex network to regulate immune reactions of hosts, activate or inhibit formation of oteoclast and lead to bone lost. The regulating function of these cytokines is important to differentiation of oteoclast in terms of lost attachment and alveolar bone resorption. Keywords:: periodontitis; immune Periodontitis is a major disease hazard to human health, one of China’s adult prevalence rate as high as 50%, which is one of the major missing teeth, the main pathological changes of inflammation of the gums, alveolar bone absorption. Nearly years found that the incidence of periodontitis, development and host defense cytokines released by cells is closely related; overlapping of functions between various factors, regulation of host immune response, leading to secondary injury of the organization; these cytokines differentiation of osteoclasts leading to the regulation of attachment loss and alveolar bone of the key. now alveolar bone loss associated with the cytokine are summarized below. Interleukin-1 (interleukin, IL) 1.1 IL-1 in the inflammatory response play an important