Retinal light damage Mechanisms of Apoptosis.doc

 PAGE \* MERGEFORMAT 13 Retinal light damage Mechanisms of Apoptosis [Keywords:] retinal light injury Mechanisms of Apoptosis Light on retinal damage, including thermal burns, photochemical damage and mechanical damage in three ways. Because the eye tissue differences in pigment distribution, mainly in the neuroepithelial layer Blu-ray absorption, the main cause retinal photochemical damage, green, and pigment epithelium in the neural epithelium absorption similar to the yellow pigment epithelium and choroid, mainly in shallow absorbed, the effect of deeper red, mainly caused by thermal effects, and high-energy laser can cause mechanical damage. apoptosis of retinal cells in one of the main results of light damage , oxidative damage, calcium homeostasis and mitochondrial damage in apoptosis plays a different role. 1 oxidative damage caused by apoptosis of retinal cells Retinal light damage in the main site of injury is usually photoreceptors [1], but there are also studies that the major damage in retinal pigment epithelial cells, Muller cells and retinal whole floor of the mitochondria [2]. Retinal cells particularly photoreceptor cells and pigment epithelium metabolically active cells, but also in the oxygen-rich environment, the appropriate frequency of the photons and oxygen molecules in the outer retinal photochemical reaction can occur to generate reactive oxygen products. arachidonic acid is a kind of membrane unsaturated fatty acids, in the role of reactive oxygen species The following may, without the role of COX-peroxidation products generated isoprostane, Tzvete Dentchev [3] in the Balb / c mouse retina extract showed that of the degree of injury increased with the corresponding optical isomer of isoprostane F2 @-VI content significantly increased, which in the past on other indicators of oxidation was consistent. membrane destruction of matter can lead to increased permeability, the membrane on both sides of a variety of substances such