Retinoblastoma pathogenesis and progress of molecular biology review.doc

 PAGE \* MERGEFORMAT 23 Retinoblastoma pathogenesis and progress of molecular biology review [Abstract] retinoblastoma (retinoblastoma, RB) is the most common form of infant eye cancer, not only seriously affect the eyesight of children, even life-threatening. With the rapid development of biology, RB biology research has made some breakthroughs, the pathogenesis of RB to inhibit tumor growth and metastasis and improve the survival rate of children has important clinical significance. now retinoblastoma pathogenesis of progress are summarized below. [Keywords:] Retinoblastoma; gene mutation, p53, murine double microsomes 2; Rb protein Abstract Retinoblastoma is a common pediatric eye malignant tumor, it not only seriously affects children s eyesight, but also endangers their lives. With the rapid development of biological technology, some breakthroughs have been made in retinoblastoma biological research. It has an important clinical significance to explore the pathogenesis of retinoblastoma in order to inhibit tumor growth and metastasis and improve the survival rate of children. Now the pathogenesis of retinoblastoma research is summarized. ?r KEYWORDS: retinoblastoma; mutation; p53; MDM2; pRb 0 Introduction Retinoblastoma (retinoblastoma, RB) occurs in infants and young children during the most common intraocular malignant tumor [1], appears the first sign of the average age of a living individual after 7mo (bilateral incidence of cases) and 24mo (unilateral incident cases ) [2], serious harm to the children’s eyesight and life, has been widespread concern in the medical profession. of about 1,000 new cases each year, accounting for new cases worldwide each year 20%. of which 30% to 40% of cases is hereditary, not entirely consistent with autosomal dominant inheritance, penetrance about 90%, 60% to 70% of cases are not hereditary. Inherited mutations in germ cells caused by the variation present in each individual cell, non-genet