Retinitis pigmentosa retinal transplantation in the treatment.doc

 PAGE \* MERGEFORMAT 19 Retinitis pigmentosa retinal transplantation in the treatment Abstract Retinitis pigmentosa is a hereditary blinding eye disease, higher rate of incidence greater harm. The clinical treatment lot, but there is no an ideal and effective method. Traditional Chinese medicine treatment, drug treatment, the rise in recent years, gene therapy and retinal transplantation own characteristics. Retinal transplantation in the treatment of which is the research hotspot in recent years, and is considered the most promising therapeutic measures. Now on the retina transplantation for the treatment of retinitis pigmentosa-related research are reviewed. Keywords: retinitis pigmentosa; retinal transplantation; retinal pigment epithelium 0 Introduction Retinitis pigmentosa (retinitis pigmentosa, RP) is a hereditary blinding eye disease, the incidence rate of about 1 / 3 500 [1]. With the four main genetic model: autosomal dominant (ADRP), autosomal recessive (ARRP), X-linked genetic (XLRP) and two genetic. In addition, mitochondrial genetic and non-hereditary form of the dissemination of laws to follow. RP was a typical sexual development, mainly in the youth, the early performance of night blindness and progressive narrowing of peripheral vision, followed by the loss of color vision may eventually lead to blindness [2], the clinical phenotype and genetic basis there is no strict correspondence between with genetic heterogeneity and clinical heterogeneity. Traditional drug therapy and medical treatment, the effect not so good. Such as the application of AMP and calcium channel blocker; traditional Chinese medicine-based drugs using blood circulation, supplemented by acupuncture, massage and acupuncture injection therapy. In recent years, found that growth factors may regulate apoptosis, the process of slow degeneration of photoreceptor cells, promoting their regeneration, can provide good conditions for retinal transplantation [