Rhubarb Ling Xian Capsule on gallstone formation after chronic liver damage effects of the intervention.docVIP

 PAGE \* MERGEFORMAT 18 Rhubarb Ling Xian Capsule on gallstone formation after chronic liver damage effects of the intervention Study: Stem Don Lee, Yu Yuan, Huang My Way, off Chung Cheng High Shan Hui [Abstract] Objective To investigate the rhubarb Ling Xian Capsule on gallstone formation in rabbits with chronic liver injury and its mechanisms of intervention. Methods 46 rabbits were randomly divided into normal group, chronic liver injury, liver cirrhosis, rhubarb Ling Xian capsule high dose group, rhubarb Ling Xian capsule low dose group. the method by subcutaneous injection of CCl4 chronic liver damage modeling, while each group for different treatment. last observed rate of gallstone formation in each group, liver function markers, pathological changes in liver , ultrastructural changes, changes in bile composition. Results chronic liver injury, liver cirrhosis positive rate of gallstone formation compared with normal control group significantly increased (P lt;0.05 or P lt;0.01. Rhubarb Ling Xian capsule high dose group, rhubarb Ling Xian Capsule small dose group compared with the positive rate of gallstone patients with liver cirrhosis was significantly lower (P lt;0.01 or P lt;0.05). liver ultrastructure in the model group were abnormal changes occur in varying degrees, rhubarb Ling Xian Capsule large, low-dose treatment group, the pathological changes of liver, liver cell ultrastructure changes were improved compared with model group, especially the high dose group. rhubarb Ling Xian Capsule large and small doses of serum AST, ALT, -GT, non-binding bile Red pigment cirrhosis group were significantly lower than (P lt;0.05 or P lt;0.01, total bilirubin, indirect bilirubin, calcium rhubarb Ling Xian Capsule large, low-dose group than in the cirrhosis group was significantly lower (P lt;0.01, low dose high dose group was significantly lower (P lt;0.01. Conclusion Rhubarb Ling Xian Capsule on gallstone formation after chronic liver injury has obvio