Riboflavin and cancer prevention.doc

 PAGE \* MERGEFORMAT 4 Riboflavin and cancer prevention [Keywords:] riboflavin Riboflavin also known as vitamin B2, is the human body, two kinds of flavin coenzyme, or flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) an important component. The two-CoA formation with a variety of protein-binding flavoprotein involved in the body’s bio-oxidation reaction and energy metabolism. Early animal studies have shown that: a lack of or use of riboflavin and its structurally similar antagonist can inhibit the growth of spontaneous tumors, but it can promote the azo dye-induced liver cancer; riboflavin may lead to a lack of upper digestive tract epithelium composition and skin inflammation, atrophy, hyperkeratosis, and even ulcers and other lesions, on this basis, easy for aromatics and various types of cancer induced by nitrosamine carcinogens. The 20th century, 80 years later, the riboflavin and human cancer prevention, reporting on the rise. An esophageal Esophageal cancer epidemiological study found a high incidence of low-incidence areas vary greatly after, Rensburg on 21 and 17 high-and low-fat staple food of local residents studies have shown that the lack of prominent high incidence of riboflavin [1]. Suh-Fang Jeng structural investigation such as through diet and blood, urine analysis, we found high incidence of esophageal cancer and Sichuan Yanting Linxian residents of riboflavin lack of a more serious [2  4]. Esophageal cancer in Henan Province of high-and low-contrast studies [5,6], Hebei Cixian [7] and the high incidence of esophageal cancer in Xinjiang [8] have also been similar results. Henan Jiyuan esophageal epithelium and cancer patients by weight riboflavin content than the normal red blood cells significantly decreased [9]. A recent case  control study shows that Iran’s Caspian Sea region with high incidence of esophageal cancer closely related to the lack of riboflavin [10]. It was also reported that the risk of esophageal ad