Runx3 in immune cells during the development of the role of Research.docVIP

 PAGE \* MERGEFORMAT 12 Runx3 in immune cells during the development of the role of Research [Keywords:] Runx3 gene in T lymphocytes dendritic cells Runx3 (Runt related transcription factor 3) gene is a newly discovered tumor suppressor gene, is a Runt domain (Runt domain, RD) transcription factor family members, participate in the regulation of cell growth and apoptosis. Research suggests that abnormal expression ( such as methylation, mutation, etc.) with a variety of malignancies, especially gastric cancer [1], recent findings, Runx3 with a variety of immune cells is also related to the genesis and development, especially in lymphocytes, development and maturity to play important role, this article Runx3 in recent years the role of immune cells reviewed the research progress. 1 Runx3 gene structure and protein expression Runx3 family of mammals, including Runx1, Runx2 and Runx3 three genes, Runx3 is one of the smallest of the family, but it has all the structural features of Runx family members, may be the basis for the evolution of the family genes. Runx3 gene is located on human chromosome 1p36, gene is 67 kb, containing p1, p2 two promoters, 6 exons and 1290 bp open reading frame. Runx3 mRNA transcription starts mainly from the product of p2 [2]. murine Runx3 gene is located 4 chromosome, and highly similar to human Runx3. Runx3 human and mouse gene has two large conserved CpG islands, including one in the vicinity of exon 2, exon 6 and another at the start site [2]. Human Runx3 protein is 415 amino acid residues in structure and Runx1, Runx2 protein similarities, by @ and subunit heterodimers formed. @ Subunit contains a 128 amino acid residues The conserved domain RD, RD domain in the amino-terminal Runx protein, contains a S-type immunoglobulin fold, Runx-mediated DNA binding protein and with core binding factor (CBF)- interaction, subunit to increase @ subunit DNA binding force, for the maintenance of its normal function is necessar