Salmeterol - fluticasone propionate inhalation therapy in the clinical observation of severe COPD_0.doc

 PAGE \* MERGEFORMAT 15 Salmeterol / fluticasone propionate inhalation therapy in the clinical observation of severe COPD [Abstract] Objective To study inhaled glucocorticosteroids (ICS) and long-acting β2 agonists (LABA premixed formulations of salmeterol / fluticasone propionate (SAL / FP) of moderate to severe chronic obstructive pulmonary disease (COPD ) treatment. Methods 70 cases of COPD patients (all patients before enrollment did not use any formulation of the hormone, receptor agonists, anticholinergic drugs, no history of oxygen therapy, were randomly divided into two groups, A group of 35 patients, inhaled salmeterol / fluticasone propionate (SAL / FP dry powder, a suction / time, 2 times / day; B group of 35 patients without inhalation of these drugs; two groups of patients were taking ambroxol 30mg / tid. observation and treatment 3 months, 6 months, December the three time points of clinical symptoms of patients, quality of life score George, lung function, blood IL 8 and TNF @ level, number of acute attack, hospitalization, hospital costs. the result of the different observation time points A, B groups lung function, St. George’s quality of life score (SGRQ), the frequency and occurrence of acute exacerbation, health status and frequency of hospitalization, and other indicators of the observed difference was significant (P lt;0.05, A group was significantly better than the B group, before and after treatment induction IL 8 and TNF @ sputum was significantly lower (P lt;0. 05, but hospital costs A, B had no significant difference (Pgt; 0.05. Conclusion ICS and LABA treatment of moderate to severe COPD has a good synergistic effect, its premixed formulations (SAL / FP 50 / 250μg) easy to use dry powder, good curative effect, has clinical value, can improve short-term level of COPD, FEV1, and no significant inhibition of systemic inflammatory response, no significant increase in medical costs. [Keywords:] Chronic obstructive pulmonary disease;