Schizophrenia-related gene polymorphism KCNN3 △.docVIP

 PAGE \* MERGEFORMAT 15 Schizophrenia-related gene polymorphism KCNN3 △ Author: Wang Hong-Cheng Shuang Shi Lu in line [Keywords:] the spirit of God schizophrenia; pathology; physiology; KCNN3 gene; polymorphism [Keywords:] the spirit of God schizophrenia; pathology; physiology; KCNN3 gene; polymorphism Ca2 activated K channel protein 3 [calcium-activated potassium (SK) channels KCNN3] as a dopamine (DA) and 5-hydroxytryptamine (5HT) pathway affect the gene, in order to find a new candidate genes provide clues. In this paper, KCNN gene family classification, chromosomal location, pathophysiological mechanisms and KCNN3 gene polymorphism and schizophrenia research in recent years. KCNN gene polymorphism in schizophrenia can be amplified TNRs interest was due to a variety of family there as early as suffering from schizophrenia who are inspired by the phenomenon of genetic, TNRs in disease severity and complex non-Mendelian genetic model is consistent. Repeat expansion detection technique to check the TNRs position, even if not found TNRs position, still found CAG / CTG repeat to the maximum length of schizophrenia patients longer than the control group. The encoded ion channel protein KCNN3 gene contains highly polymorphic polyglutamine repeat of (CAG) n and a rare deletion contains four bases found in schizophrenia patients, thus making research KCNN3 gene polymorphism associated with schizophrenia is very popular in recent years. 1 KCNN gene classification and distribution of 1.1 Classification KCNN gene is divided into four categories: KCNN1, KCNN2, KCNN3, KCNN4, they were also known as KCa2.1, KCa2.2, KCa2.3, KCa3.1. 1.2 Distribution of KCCN more distributed in the cerebral cortex, hippocampus, ventral tegmental, septal area, supraoptic nucleus, substantia nigra, thalamus, at the end of the hypothalamus, caudate nucleus, the amygdala, basal ganglia, stiff core and so on. 2 KCNN gene mapping 2.1 The above-mentioned four types of gene mapping genes