Selective COX2 inhibitor Celecoxib to prevent postoperative abdominal adhesions in rats Experimental Study.docVIP

 PAGE \* MERGEFORMAT 16 Selective COX2 inhibitor Celecoxib to prevent postoperative abdominal adhesions in rats Experimental Study Of: Wang Hong, Li Xu Qi, Weiguang Bing, XU Xin, flat peak [Abstract] Objective Celecoxib on postoperative intraperitoneal adhesion formation in rats preventive effect and its mechanism. Methods 80 SD rats were randomly divided into 5 groups: patients treated with peritoneal abrasions as the A group, patients treated with peritoneal abrasions +40 mg / (kg d) Celecoxib for the B group, patients treated with peritoneal abrasions +20 mg / (kg d) Celecoxib for the C group, patients treated with peritoneal abrasions sodium hyaluronate for the H + group received only open the abdomen was closed sham operation for the S group. half of the rats in each group were 8 and 15 days after death, the naked eye assessment of general and abdominal adhesions in rats the degree of adhesion was detected by immunohistochemical tissue VEGF and CD34. Results Group 5 the degree of postoperative adhesion in rats with differences between the groups was significant (P lt;0.01, B group, C group, adhesion scores were significantly lower than H group, A group. VEGF protein expression in group A the most, followed by H, respectively group, C group, B group, S group of the weakest. CD34 expression in group A the most, followed by H group, respectively, C group, B group, S group is the weakest. Conclusion Postoperative Celecoxib may be effective in preventing short-term oral rat intraperitoneal adhesion formation, better than the sodium hyaluronate gel. mechanism may be reduced after the inhibition of COX 2 activity of VEGF expression and inhibit the occurrence of adhesive tissue neovascularization. [Keywords:] abdominal adhesions, cyclooxygenase 2, angiogenesis, Celecoxib ABATRACT: Objective To determine the preventive effect of Celecoxib on postoperative adhesion formation and its mechanism. Methods We divided 80 SD rats into 5 groups: Groups A, B, C