Selenium intervention in experimental rat liver fibrosis Research.docVIP

 PAGE \* MERGEFORMAT 8 Selenium intervention in experimental rat liver fibrosis Research [Keywords:] liver fibrosis Liver fibrosis is caused by a variety of causes of chronic liver disease a common pathological process is a necessary stage of cirrhosis of the liver. The pathological characterized by periportal area and hepatic lobule in a large number of abnormal proliferation of fibrous tissue deposition, leading to structural deformation of the liver, causing liver damage or further aggravate. The study found that the continued development of liver fibrosis, 25% to 40% eventually develop cirrhosis of the liver. The mechanism of liver fibrosis is extremely complex, mainly of liver extracellular matrix (ECM) and abnormal deposition of excessive increase, which is the liver as a response to chronic injury. Whether the reversal of hepatic fibrosis has been a controversial issue in recent years, molecular biology and liver cell separation technology, the mechanism of liver fibrosis has been part of the states that liver fibrosis is currently considered a reversible lesions [1], if the period of active treatment of liver fibrosis, the prognosis will be greatly improved. However, at home and abroad are still short of an ideal anti-hepatic fibrosis drugs, clinical treatment is still at the exploratory stage, while animal experiments to clinical research can provide practical and theoretical basis, therefore anti-hepatic fibrosis in experimental studies have also become more important. Selenium is an essential life activities, one of the trace elements, which constitute the glutathione peroxidase (GSH-Px) an important part of a catalyst reduced glutathione (GSH) into oxidized glutathione (GSSG), so that the toxic peroxides into non-toxic hydroxyl compounds. At the same time, selenium with catalase, superoxide dismutase (SOD), vitamin E, vitamin C, carotenoids and other lipid oxidase pathway to join, the main function is to remove all kinds of oxygen free radicals