某院住院患者甲硝唑联用情况分析.PDFVIP

某院住院患者甲硝唑联用情况分析 肖尔佳 1，2 ＊ ，张 亮 1 #，钟明康 （1 1.复旦大学附属华山医院药剂科，上海 200040；2.复旦大学药学院，上海 201203） 中图分类号 R95 文献标志码 A 文章编号 1001-0408（2014）08-0744-03 DOI 10.6039/j.issn.1001-0408.2014.08.23 摘 要 目的：为提高甲硝唑的临床合理用药水平提供参考。方法：查阅2012年7－12月某院使用过甲硝唑的住院患者的病历资 料，统计其联合用药情况并进行分析。结果：共 546 例患者使用过甲硝唑，以预防为目的的用药占 47.81％（261 例），以治疗为目的 的用药占 52.19％（285 例）。有 97.80％（534 例）的患者使用甲硝唑时联用了其他抗菌药物，共联合用药 599 次，其中不合理联用占 20.70％（124 次）。使用次数最多的联用方案为甲硝唑+头孢呋辛，不合理联合用药次数最多的方案为甲硝唑+头孢哌酮/舒巴坦。 结论：甲硝唑的不合理联合用药在临床中比较常见，亟需引起临床工作者足够的关注，进一步规范抗厌氧菌药物的合理应用。 关键词 甲硝唑；联合用药；合理用药；使用情况 Analysis of the Combination of Metronidazole in the Inpatients from a Hospital XIAO Er-jia1，2，ZHANG Liang1，ZHONG Ming-kang（1 1.Dept. of Pharmacy，The Affiliated Huashan Hospital of Fudan University，Shanghai 200040，China；2.School of Pharmacy，Fudan University，Shanghai 201203，Chi- na） ABSTRACT OBJECTIVE：To provide reference for the improvement of rational use of metronidazole in the clinic. METHODS： Medical records of inpatients receiving metronidazole during Jul.-Dec. in 2012 were retrospective reviewed and information about drug combination was extracted and analyzed statistically. RESULTS：546 patients were treated with metronidazole，prophylactic drug use accounted for 47.81％（261 cases）and drug treatment accounted of 52.19％（285 cases）. In most of patients，metronida- zole was prescribed combining with other drugs，which accounted for 97.80％（534 cases）. The total number of drug combination with metrinidazole was 599 times，20.70％（124 case）of which was irrational. The most frequent combination was metrinidazole+ cefuroxime，while the most frequent irrational combination was metrinidazole+cefperazone/sulbactam. CONCLUSIONS：Irrational drug combination of metronidazole has become a very common problem in clinic，especially in some special departments，which should