Small RNA and its application in malignant lymphoproliferative disease the role of research.docVIP

 PAGE \* MERGEFORMAT 35 Small RNA and its application in malignant lymphoproliferative disease the role of research Abstract genome in plants and animals there is a broad class of non-protein-coding RNA genes, resulting in the length of about 19-25 nucleotides RNA, they are named small RNA (microRNA, miRNA). This is a class of activity in regulating expression of other genes of small RNA. In the biological developmental processes play an important role. In this paper, the characteristics of these genes, biological function, generation and mechanism of action and in malignant lymphoproliferative diseases, the role of research are reviewed. Keywords: miRNA; non-coding RNA; malignant lymphoproliferative disease Progress on the Research of MicroRNA and Its Functions in Lymphoid Malignancies - Review Abstract Plant and animal genomes contain an abundance of small genes that produce RNAs of about 22 nucleotides in length, which was dubbed as microRNA (miRNA). These newly found endogenous RNAs may participate in a wide range of genetic regulatory pathways and play an important role in the organism development. This paper reviewed the recent studies and progress on the characteristics, functions and mechanisms of the microRNAs, as well as the advances of research on lymphoid malignancies. Keywords: miRNA; non-coding RNA; lymphoid malignancies For many years, DNA and protein in genomic research has been the protagonist, while the RNA and from just being seen as the messenger between DNA and protein only. Recently, more and more evidence has clearly indicated, RNA in almost all animal and plant species play a role in earlier than we expect active. Eukaryotes, there are two major non-coding RNA (non-coding RNA), and play an important role. One for the small interfering RNA (small interfering RNA, siRNA), the other for the small RNA (microRNA, miRNA). miRNA is a size of 19-25 nt single-stranded small molecule RNA, the first to be