Source of seed cells for cartilage tissue engineering Research Progress.docVIP

 PAGE \* MERGEFORMAT 32 Source of seed cells for cartilage tissue engineering Research Progress Author: Wang Cuifang, Feng Wan-wen, Wu Tianyou, Masayoshi Son Keywords: source of seed cells for cartilage tissue engineering Causes a variety of articular cartilage lesions are more common, a lack of self-healing capacity of cartilage injury, cartilage defect repair has been a clinical problem. With the cell biology and materials science of the rapid development of tissue engineering technique to repair damaged rickets has become possible, but the optimum seed cell source is the application of this technology, the premise and key [1]. In this paper, the source of seed cells for cartilage tissue engineering optimization of the acquisition, the problems and their solutions and other research are reviewed. A cartilage tissue engineering requirements of the source of seed cells The seed cells for cartilage tissue engineering should meet the following requirements: a rich source of material selection to facilitate; a strong proliferation of passage capacity; after inoculation with the carrier materials to maintain proliferation and a higher adhesion rate, implanted by the zone to maintain repair tissue table type; on the body or for a small lesion in the clinical application of bio-security and no obvious immune rejection and other potentially dangerous [2]. 2 seed cells for cartilage tissue engineering source 2.1 autologous chondrocyte Theoretically, autologous cartilage tissue engineering cartilage cells are the best source of seed cells, not only the same functionality, there is no immune rejection response, but also induced differentiation does not require training. However, studies have shown that the concentration of seeded cells (5 ~ 6) × 107/ml, the formation of new cartilage in the best shape, but the limited autologous cartilage derived, cartilage cell proliferation is low, difficult to achiev