Statins Progress pleiotropic.docVIP

 PAGE \* MERGEFORMAT 23 Statins Progress pleiotropic Keywords: statins; pleiotropic Statins for the 3 3 hydroxy-methyl coenzyme A reductase inhibitors, clinically used to lower cholesterol. With his depth study of statins, statins an encouraging multi-effect, including increased nitric oxide bioavailability, repair of damaged endothelium, anti-inflammatory, antioxidant, promoting angiogenesis, stable atherosclerosis (AS) plaques, the mobilization of endothelial progenitor cells, cardiac hypertrophy, Antiarrhythmic 1 and so on. Statins pleiotropic mechanism may be unrelated to its lipid-lowering effects. As has been observed that when the lipid-lowering effect has not appeared, statins have pleiotropic effects occurred 2. Currently statins pleiotropic cardiovascular field has become a hot debate and exploration, led clinicians and researchers attention. 1 statins anti-inflammatory effect Clinical research data show statins can significantly reduce a variety of inflammatory mediators in patients 3, inhibition of inflammatory cytokines, chemokines and adhesion molecule expression, decreased C reactive protein (CRP) levels. In the REVERSAL trial atorvastatin than pravastatin have a stronger role in reducing CRP 4. Newly released TARA 5 study shows that atorvastatin treatment for 6 months after the disease active points (DAS28) improved significantly, CRP and ESR indicators also improved significantly. Numerous clinical studies suggest that statins have a unique anti-inflammatory effect. The anti-inflammatory mechanisms of action include decreased chemotaxis of inflammatory cells within the plaque and aggregation, inhibit macrophage and soluble intercellular adhesion molecule expression of metalloproteinases, among which macrophages and to reduce interleukin 6 (IL 6) synthesis is the main mechanism. Statins anti-inflammatory effect is to reduce the production of proinflammatory cytokines, evidence of basic research in this area a lot. Bel