TGF-β signaling in hematopoietic development of the role of.docVIP

 PAGE \* MERGEFORMAT 34 TGF-β signaling in hematopoietic development of the role of Abstract hematopoietic development, including embryonic and adult hematopoietic place the maintenance of steady-state hematopoiesis. As an important model organism for the study of hematopoietic development in mice provides a very good model. Transforming growth factor-β (TGF-β) as an important factor in hematopoietic regulation are more and more attention. Systematic study of TGF-β signaling in mammalian ontogeny of physiological conditions on the occurrence and development of the role of blood, with the gene knockout technology, to establish and mature possible. In this paper, to mice were studied in recent years, applied gene knockout, dominant negative effect of genetically modified and other means to build a TGF-β signaling molecules missing an individual’s blood-related phenotype and other research are reviewed in order to further clarify the TGF-β signaling in the occurrence and development of the hematopoietic effect and possible mechanism. Keywords: transforming growth factor-β; gene knockout; of hematopoietic; of hematopoietic growth TGF-β Signaling during Hematopoietic Development - Review Abstract Hematopoietic development is characterized by the dynamic generation of hematopoietic stem / progenitor cells during embryogenesis, and afterward, the maintaining of hematopoietic homeostasis in adult. Mouse model has been appreciated valuable for dissecting the regulatory mechanisms of hematopoietic development. As an important cytokine playing pivotal and versatile roles in the regulation of hematopoiesis, transforming growth factor-β (TGF-β) attracts more and more attention. In particular, gene targeting by homologous recombination provides a key means for systematic evaluation of how TGF-β signaling is involved in hematopoiesis under physiological conditions. To further illustrate the functions and possible mechanisms of TGF-β in hematopoieti