The application of antiviral drugs and children with viral infections.docVIP

 PAGE \* MERGEFORMAT 22 The application of antiviral drugs and children with viral infections [Keywords:] antiviral drugs, viral infectious disease of children Infectious diseases are still common diseases of children, and frequently-occurring disease, the virus infection in children, the most common pathogen, is different from the past that antiviral drugs can effectively inhibit the bacterial antibiotic, as inhibit viral replication, the virus soon invade host cells and in which the replication, damage to normal cells will be inevitable. Antiviral effects of past poor and side effects and therefore viral infections in children less application. As in recent years, in-depth study of the virus characteristics, as well as confirmation of the virus-specific enzymes, the development and application of antiviral drugs have a greater development of these drugs mainly through interference with virus attachment or interference with the virus into the host cell, interference Shelling the virus inhibition of viral replication. There are currently more antiviral drugs used in pediatric clinical. An anti-herpes virus drugs [1  4] Herpes virus is the more common childhood virus, the virus has eight kinds of types of antiviral drugs, of which four kinds of virus infection (HSV  1, HSV  2, VZV, and CMV) there is a genuine effect. Anti-herpes virus drugs are two categories: (1) nucleoside and nucleotide analogues: Acyclovir (ACV) / Valeriana Famciclovir (VACV), cidofovir (Cidofovir), the Pan-Xi Luowei (Famciclovir ) / spray Xiluo Wei (Penciclovir), ganciclovir (Ganciclovir) / Valganciclovir (Valganciclovir); (2) inorganic phosphate analogues: phosphonic acid (Foscarnet). 1.1 Anti-herpes simplex virus (HSV) infection in drug Primary HSV infections occur in childhood, mostly sub-clinical manifestations. In the primary infection, the virus lurking in the dorsal root ganglia, in a different state, is activated and the relapse. Differences in clinical manifestations