The development of selective β2 receptor agonists and clinical application.docVIP

 PAGE \* MERGEFORMAT 20 The development of selective β2 receptor agonists and clinical application [Keywords:] selective β2 receptor agonists, development and clinical application Selective β2 receptor agonists is the most widely used clinically, the widest range of bronchial spasm agents, particularly inhaled β2 agonists have been widely used in the treatment of acute attack of bronchial asthma, which can effectively relieve acute asthma symptoms. In this paper, the development of selective β2 receptor agonists and the recent clinical application are reviewed. 1 β2 agonist overview of development clinical application of β-receptor agonists has been nearly a hundred years of history of asthma, were found in the early 20th century, including ephedrine, epinephrine, isoproterenol and other adrenergic agonists, because these drugs on the β2 adrenergic receptor selectivity is poor, with a strong cardiovascular side effects, is now rarely used in the treatment of bronchial asthma. Since the 20th century, 60 years since the selective strong, good efficacy and few side effects of short-acting β2 receptor agonist into clinical gradually since then have found more than 30 β2 receptor agonist. into the late 80s, with the emergence of long-acting β2 agonists, so that the number of daily drug use from the previous 4 to 6 times reduced 1 or 2 times, particularly in conjunction with inhalation administration, in alleviating the symptoms of asthma made good results. At the same time as these long-acting β2 agonists on the β2 adrenergic receptor has strong selectivity, greatly reducing the side effects incidence. In recent years, many pharmacologists and molecular pharmacology of asthma experts from the level of β2 agonists on the mechanism of asthma were more in-depth research, and made great progress, but also to β-2 receptor more selective agonists, efficacy of new formulations continue to come out better, so that β2 agonists relieve acute asthma symptoms beco