The progress of nitric oxide in emergency medicine and its application.docVIP

 PAGE \* MERGEFORMAT 14 The progress of nitric oxide in emergency medicine and its application In recent years, people gradually realize that a release by the endothelial cells may be mediated by vasoactive substances of blood vessels Relaxation response, a substance known as endothelium-derived relaxing factor (EDRF). Because of this physical half-decline Period is very short, difficult to detect in vitro, so its exact composition has been unclear. In 1987, Palmer and Mo ncada other 〔 1,2〕 respectively, confirmed that EDRF and nitric oxide (NO) has the same attributes, and then prove that Kinds of vascular endothelial-derived relaxing factor is NO. In vivo vascular endothelial cells, platelets, neutrophils, Macrophage cells, nerve tissue can be produced in certain stimulated NO, recent studies have shown that, NO involved in a wide range of physiological Function of regulation, such as blood pressure regulation, peripheral non-adrenergic non cholinergic (NANC) neurotransmitter delivery , Immune-mediated and defense mechanism, in the emergency critically ill patients in the incidence and treatment of great significance. Is On the NO in the emergency medicine research in the field reviewed.  1.NO biological synthesis and NO synthase (NOS) Under the action of the NOS, L-arginine (L-Arg) into L-citrulline in the process of generating NO, a variety of materials Can have an impact on this process. NO half-life is very short, about 5 ~ 10 seconds, it is rapidly oxidized to NO2 in vitro -2 And NO-3, which at present there is a certain difficulty to directly detect NO more to test its metabolites NO2-2 , NO-3 to represent the NO generation. NO could also be oxygen free radicals, hemoglobin and other heme-containing protein binding Accelerate the inactivation, while the superoxide dismutase (SOD) could inhibit its inactivation. NOS in the NO synthesis process, the focus To the role. There are two subtypes of NOS are known, a basic-type NOS  (c-NOS 