The role of p120ctn in tumors.docVIP

 PAGE \* MERGEFORMAT 19 The role of p120ctn in tumors Keywords: p120ctn-cadherin tumor suppressor 0 Introduction p120 catenin (p120ctn) is a member of the Armadillo family of structural proteins. It is located in cell junctions and the nucleus, and E-cadherin highly conserved juxtamembrane domain (JMD) interaction, thus to participate in E-cadherin-mediated signal transduction and adhesion processes. Were found in a variety of malignant tumors have abnormal expression of p120ctn, suggesting that its invasion and metastasis of malignant tumors may have a role. In this paper, the molecular mechanism of p120ctn the latest research advances and its possible role in the tumor are reviewed. 1 p120ctn the molecular basis of The molecular structure of 1.1 p120ctn p120ctn was originally Src oncoprotein as a substrate was found, is now regarded as a kind of infiltration and metastasis of cancer cells related to-catenin. Catenin (catenin) are adhesion molecules and intracellular signaling molecules, their family members, including α , β , γ  catenin, and p120ctn. β , γ  catenin in mutually exclusive manner with cadherin-catenin-binding domain (CBD) closely, while the other end with the combination of α  catenin, which in turn with the actin cytoskeleton with the formation of E-cadherin complex. The complex on the maintenance of cells in the normal signal transduction and cell adhesion are necessary. The end of p120ctn and E  cadherin combination of near-membrane area, the other end does not combine with the α  catenin, indicating p120ctn in E-cadherin complex has a special function. p120ctn gene cloning has revealed that it includes a central Armadillo repeat region, an implementation of the regulatory function of the N-terminal sequence and a carboxy-terminal sequence of unknown function. 1.2 p120ctn subtypes p120ctn by N  terminal and C  end of the transcription start site of exon splicing generate