The role of thyroid hormone caused by cardiac hypertrophy mechanisms and traditional Chinese medicine for its intervention.docVIP

 PAGE \* MERGEFORMAT 41 The role of thyroid hormone caused by cardiac hypertrophy mechanisms and traditional Chinese medicine for its intervention 【Abstract】 Objective To thyroxine caused by the mechanism of cardiac hypertrophy and related information on Chinese herbal medicine intervention were reviewed. Methods to summarize relevant literature in recent years to introduce. The results of excessive thyroxine (L-Thyroxine, Thy) can lead to cardiac hypertrophy, its mechanism complicated, not only the direct effect of hormones on the heart, but also mediated by Ca2 transit, resulting in oxygen free radicals, so that ATP depletion and with the activation of renal Su-angiotensin system, increased adrenergic receptor expression and other relevant, it is a kind of cardiac hypertrophy caused by hypoxia-ischemia special hypertrophy. Has preliminarily found that some Chinese medicine and Chinese herbal compound with thyroxine antagonism and prevention of cardiac hypertrophy. Conclusion thyroxine caused by the mechanism of cardiac hypertrophy and development of identified anti-thyroxine and inhibitory effects of cardiac hypertrophy in-depth study of Chinese medicine needed. Keywords: thyroid hormone; cardiac hypertrophy; role of the mechanism; traditional Chinese medicine The Mechanism of Thyroxin Induced Myocardial Hypertrophy and the Intervention of Chinese Herbs Abstract: ObjectiveTo review the mechanism of thyroxin inducing myocardial hypertrophy and the intervention of Chinese herbs on it. MethodsThe correlative documents published in recent years were summarized.ResultsMyocardial hypertrophy can be induced by excessive L-Thyroxine. The mechanism is complex, including the direct impact of the hormone on the heart and the transportation of Ca2, which results in producing oxygen free radicals and the consuming of ATP. L-Thyroxine accelerates myocardial hypertrophy process by stimulating rennin-angiotensin system and increasing the expressio