Systemic inflammatory response syndrome and cardiopulmonary bypass details.docVIP

 PAGE \* MERGEFORMAT 19 Systemic inflammatory response syndrome and cardiopulmonary bypass details Cardiopulmonary bypass (Cardiopulmonarybypass, CPB) to make open-heart surgery possible, but because It is a ‘controlled shock’ process, can lead to systemic inflammatory response syndrome (Systemicinflamm atoryresponsesyndrome, SIRS), thus affecting the effect of cardiac surgery. CPB open-heart surgery is A complex to stimulate the process, both physical factors, such as surgical trauma such as mechanical stimulation, there are chemical irritants, such as the CPB, inflammatory mediators, cytokines, etc., coupled with the different body reactions, so that the performance of signal transduction after CPB Complex form. The pathogenesis of SIRS after CPB has not yet been fully clarified, and now more recognized as a ‘second hit Strike ‘doctrine, CPB stress can lead to a first-strike, so that immune cells are activated; such as re - Intestinal bacterial translocation occurs, ischemia - reperfusion injury, etc. The second attack can be caused by uncontrolled inflammatory response, effects of fine Cellular release of inflammatory mediators and leading to a cascade effect, continuous amplification of systemic inflammatory response, affecting the normal function of organs, Even cause or speed up the single or multiple organ dysfunction or failure from occurring. In this process, the excessive anti-inflammatory Should activate the effector cell and the release of inflammatory cytokines play an important role. The emergence and development of SIRS is an extremely A complex cascade process, their severity is mainly the downstream pro-inflammatory cytokines (TNF-α , IL-6, IL-8, etc. ), And anti-inflammatory cytokines (IL-10, etc.) equilibrium decision. Therefore, the study and explore the SIRS after CPB Citation From the date of the release of various cytokines and changes in the law, as well as to clarify the mechanisms and affecting factors that change has bec