Systemic treatment of HFMD.docVIP

 PAGE \* MERGEFORMAT 22 Systemic treatment of HFMD [Keywords:] hand foot and mouth disease, systemic treatment HFMD is caused by the foot and mouth disease caused by enterovirus infections was first reported in New Zealand .1957 .1958 .1959 of Coxsackie virus isolated in the hand, foot and mouth disease a name. Early detection of the pathogen of hand, foot and mouth disease mainly type for the COX 16, 1969 EV 71 was first recognized in the United States, after alternating between the two, every 2 to 3 years can cause an epidemic. for the common diseases of the hand, foot and mouth disease, but outbreaks in recent years, and often accompanied by popular higher mortality rate [1], especially its central nervous system caused by the deadly disease and myocardial damage, and since May 2, 2008 are included in Class C infectious diseases, the diagnosis and treatment of the disease are more doctors who know the re- . so the disease is particularly important in the early systemic medication, is systemic treatment for hand, foot and mouth disease cases are summarized below. 1 anti-DNA and RNA virus drug Ribavirin, also known as ribavirin, is a broad-spectrum antiviral drugs. Has a strong hypoxanthine monophosphate dehydrogenase inhibitor, can inhibit the IMP -5-- phosphate dehydrogenase, blocking the muscle guanine nucleotide into acid, thereby inhibiting viral RNA and DNA synthesis, DNA and RNA virus replication are inhibited. He Bei [2], 28 cases of hand, foot and mouth disease in children using ribavirin (ribavirin 10 mg / (kg · d join an intravenous infusion of glucose, and 20 cases of use of poly 1 ~ 2 mg intramuscular injection of a control group, the results significantly better than the control group, markedly effective rate, the total efficiency on significant difference. Zhuli Rong et al [3] 54 cases of the disease in children in the use of ribavirin 15 ~ 20 mg / (kg · d by adding glucose solution intravenously, has had a noticeable effect. 2 an