Troponin in patients with acute coronary syndrome diagnosis of Progress.docVIP

 PAGE \* MERGEFORMAT 17 Troponin in patients with acute coronary syndrome diagnosis of Progress [Keywords:] troponin in acute coronary syndrome Acute coronary syndrome (ACS) is the basis of coronary plaque instability characteristics, and can cause acute cardiac insufficiency in a group of syndromes. Including unstable angina pectoris (UAP), acute myocardial infarction (AMI) and sudden cardiac death, with the incidence of acute and dangerous nature of large features. With the development of laboratory techniques, the new cardiac markers cardiac troponin (cTn) testing have become an increasing concern, they have a high degree of myocardial damage sensitivity and specificity, and can predict the risk of myocardial ischemia in patients. 1cTn and ACS cTn is a striated muscle structural protein, a single-chain polypeptide from the three complexes formed, is the regulation of myocardial contraction protein, found in myosin and actin surface, including cardiac troponin T (cTn T), troponin I ( cTn I) and troponin C (cTn C) three sub-units to form a complex co-regulation of myocardial contractility. ACS by the pathological changes in coronary plaque rupture, surface damage or cracks, followed by bleeding and thrombosis, caused by coronary artery due to incomplete or complete obstruction, accounting for about 30% of coronary heart disease. Of various types have different degrees of myocardial injury and different prognosis, great harm, maiming and killing the Chinese population has become one of the main men than women [1]. Study found that artery plaque rupture leading to ACS is the main mechanism, cTn is a cardiac-specific calcium-binding protein, under normal circumstances, the concentration of its circulation is very low, when the myocardial necrosis, when released into the circulation, in myocardial necrosis after 4 ~ 6 h peripheral blood can be measured out, so they have a high degree of sensitivity to myocardial necrosis. In addition, cTn T and cTn I also ha