Ⅱ collagen sponge material properties and the impact of cartilage defects.docVIP

 PAGE \* MERGEFORMAT 21 Ⅱ collagen sponge material properties and the impact of cartilage defects Of: Liu Ying Yeung, Chen Honghui, Yang Xiaohong, Liang Pei-Hong, Dai Li Bing, see Yung-Tan [Abstract] [Objective] Ⅱ material properties of collagen sponge in the repair of cartilage defects in their role. [Methods] Contrast Ⅱ Ⅱ collagen sponge and collagen membrane mechanics, material properties such as pore size differences between areas, and rabbit articular cartilage defect model, A group received transplantation of type Ⅱ collagen sponge, B group received transplants of type Ⅱ collagen membrane, and C group was the control group, no treatment after surgery, respectively, 2,6 and 12 weeks derived, through the organization Studies of cartilage defect repair were observed effect. [results] Ⅱ Ⅱ collagen sponge and collagen membrane material properties were significantly different on the collagen layer autofluorescence obtained by image analysis scanning an average pore size of A group (93.26 + - 38.41) μm, elastic modulus (0.098 + -0.0 017) MP/m2, more desirable than B group. A group of 6 histologically Zhou Shisheng into a large number of new cartilage, new cartilage forms at 12 weeks and is close to maturity normal, compared with B, C group more superior. [Conclusion] Ⅱ collagen sponge has the ideal aperture and reasonable nature of the biomechanical structure is conducive to the repair of cartilage defects is a good material properties of the tissue engineering matrix. [Keywords:] tissue engineering; Ⅱ collagen; Biomechanics; aperture; cartilage defects Abstract: [Objective] To study the material characteristics of collagen type Ⅱ and its efficacy in repairing cartilage defect. [Methods] Differences in material characteristics such as mechanism, pore-diameter between the two kinds of materials were compared.The cartilage defect model of rabbit knee joint were constructed.In group A, cartilage defects was repaired by spongy-collagen type Ⅱ. In group B