β lactam antibiotics progress of effect after_0.docVIP

 PAGE \* MERGEFORMAT 18 β lactam antibiotics progress of effect after [Abstract] Objective: In recent years, domestic and foreign β-lactam antibiotics on the after-effects of a lot of exploration and research, evaluation of post-antibiotic effect has become an important new antibiotic pharmacodynamics one of the parameters, and to design more rational clinical The dosage regimen provides a new idea. This comprehensive relevant literature to the concept of post-antibiotic effect, mechanism, characteristics and significance of clinical medicine are reviewed. [Keywords:] β lactam antibiotics, PAE, PASME, PLIE β-lactam antibiotics (β lactam antibiotics) is the chemical structure of β-lactam ring containing a class of antibiotics. including penicillins, cephalosporins, monocyclic β-lactams, Carbapenems and β lactamase antibiotics and β-lactamase inhibitors such as compound formulations. As such a wide variety of antibiotics, antimicrobial activity is strong, broad spectrum antimicrobial, safety, and has been widely used in clinical, pharmaceutical industry is an important new field of antibiotic development . At present, the clinical administration of antibiotics depends on the program to establish the pharmacokinetics and pharmacodynamic parameters, including after-effects of antibiotics is one of the important parameters. With post-antibiotic effect of the deepening of the development regimens have become more scientific and reasonable. 1 For the concept of postantibiotic effect Antibiotic effect (post antibiotic effect, PAE) as early as 1946, so that Jibei Parker, but never pay attention until 1977, McDonald and so the concept was proposed PAE [1]. PAE is a short contact with bacteria and antibiotics , when the antibiotic was removed, bacterial growth is still inhibited by the continuing effects of antibiotics on pathogenic micro-organisms it is specific effects. postantibiotic sub-MIC effect (post antibiotic sub MIC effect, PASME) was first propos